SEANOL® 的安全性如何？
Seanol® is a mixture of purified, bioactive compounds called phlorotannins from Ecklonia cava. It is a safe food ingredient that has been approved by major FDAs around the world.
[1]
無副作用
經過六次臨床試驗*及已售出超過 13,000 瓶，目前尚未有報告顯示任何副作用。
[2]
FDA 認可成分
Seapolynol®更獲美國、歐洲、韓國和愛爾蘭的食品及藥物管理局認可為新膳食成分 (NDI)，即其安全性已經過許多政府組織的獨立審查和認可。
It is the only Ecklonia cava extract that can be legally sold in these countries.
[3]
經挑選與純淨的化合物
Seanol® 比全天然提取物更純淨。
Seanol® contains only specific compounds called phlorotannins, and the purification process removes any environmental contaminants such as iodine, iron, lead or other heavy metals.
[4]
研究性新藥
Ecklonia cava phlorotannins, under the name PH100, was approved as an Investigational New Drug (IND) by the United States FDA in 2013. It is undergoing clinical trials in the United States and in other countries.
Ecklonia cava phlorotannins are not yet approved as drugs, but are being investigated in humans for treatment of various conditions.
* 臨床試驗的參考文獻
1. Kim J, Jung Y, Lee E, Jang S, Ryu DH, Kwon O, Hwang GS. Urinary Metabolomic profiling analysis and evaluation of the effect of Ecklonia cava extract intake. Nutrients. 2020 May 14;12(5):1407. doi: 10.3390/nu12051407. PMID: 32422870; PMCID: PMC7285171.
2. Oh JK, Shin YO, Yoon JH, Kim SH, Shin HC, Hwang HJ. Effect of supplementation with Ecklonia cava polyphenol on endurance performance of college students. Int J Sport Nutr Exerc Metab. 2010 Feb;20(1):72-9. doi: 10.1123/ijsnem.20.1.72. PMID: 20190354.
3. Lee SH, Jeon YJ. Efficacy and safety of a dieckol-rich extract (AG-dieckol) of brown algae, Ecklonia cava, in pre-diabetic individuals: a double-blind, randomized, placebo-controlled clinical trial. Food Funct. 2015 Mar;6(3):853-8. doi: 10.1039/c4fo00940a. PMID: 25608849.
4. Shin HC, Kim SH, Park Y, Lee BH, Hwang HJ. Effects of 12-week oral supplementation of Ecklonia cava polyphenols on anthropometric and blood lipid parameters in overweight Korean individuals: a double-blind randomized clinical trial. Phytother Res. 2012 Mar;26(3):363-8. doi: 10.1002/ptr.3559. Epub 2011 Jun 30. PMID: 21717516.
5. Lee DH, Park MY, Shim BJ, Youn HJ, Hwang HJ, Shin HC, Jeon HK. Effects of Ecklonia cava polyphenol in individuals with hypercholesterolemia: a pilot study. J Med Food. 2012 Nov;15(11):1038-44. doi: 10.1089/jmf.2011.1996. PMID: 23126663.
6. Lee HJ, Kwon O, Kim JY. Supplementation of a polyphenol extract from Ecklonia cava reduces body fat, oxidative and inflammatory stress in overweight healthy subjects with abdominal obesity: A randomized, placebo-controlled, double-blind trial. J Funct Foods. 2018 Jul;46:356-364. doi: 10.1016/j.jff.2018.04.062.